Ways to prevent instruments from interfering with each other

What are some of the best ways to prevent instruments from interfering with each other besides subtractive EQ? And how often would you say you use subtractive EQ?

Subtract eq is a powerful tool. So is additive eq. Panning is another big one. Sometimes a small amount of pitch modulation can set something apart as can a small amount of short delay or distortion.
Learning a bit of how the human brain processes sight and sound can guide you. With sight and sound it can take a lot of effort to focus on a detail when it all looks or sounds similar but one very tiny change or movement awakens your senses to that one area and bam!!..focus.
Contrasts are Key.

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Thank you for the response @Tchad_Blake! Lately I’ve been thinking a lot about how contrast and context can play such important roles.